Endocrine Abstracts

Obesity and diabetes mellitus type 2 are proinflammatory states associated with increased disease severity in rheumatoid arthritis (RA). Weight loss is associated with improved disease activity in rheumatoid arthritis (RA). Furthermore science experiments demonstrated weight-independent anti-inflammatory and immunomodulatory effects of GLP-1 receptor agonists. Moreover, in vitro studies found anti-inflammatory effects of GLP-1 receptor agonists in fibroblast-like syno...

Superoxid dysmutase (SOD) is a key antioxidant enzyme engaged in detoxication of superoxide radicals. Ala/Val substitution in Mn SOD leads to a change in the effectiveness of the action of the enzyme. This polymorphism we analyzed among several groups patients with diabetes and we compared with control group of healthy volunteers. It is proved an association connection of tracked marker in some of the groups of patients with diabetes compared to the rest population sample. Suc...

IntroductionThe development of Diabetes mellitus type 1 (DMT1) is considered as an autoimmune pro-inflammatory process. Human enteroviruses are thought to be also a cause. These viruses influence beta cells and cause expression of immunological factors. The affected cells destroy the related beta cells. The aim of the work is to study the genetic polymorphisms in IP-10/CXCL10 and its receptors CXCR3 and TLR4 in order to predict expression of DMT1.<p ...

Interferon gamma-induced protein 10, a proinflammatory chemokine, has a significant effect in inflammatory diseases. Interferon-inducible protein of 10 kD (IP-10/CXCL10), is a member of the C-X-C chemokine superfamily. It is a potent chemoattractant for activated T lymphocytes and is reported to be involved in various disease states, including atheroma plaque formation, inhibition of tumor angiogenesis and maintenance of podocyte function. However, the involvement of IP-10 in ...